pH-sensitive intracellular photoluminescence of carbon nanotube-fluorescein conjugates in human ovarian cancer cells.

نویسندگان

  • M T Chen
  • L M Gomez
  • F N Ishikawa
  • P T Vernier
  • C Zhou
  • M A Gundersen
چکیده

To add to the understanding of the properties of functionalized carbon nanotubes in biological applications, we report a monotonic pH sensitivity of the intracellular fluorescence emission of single-walled carbon nanotube-fluorescein carbazide (SWCNT-FC) conjugates in human ovarian cancer cells. Light-stimulated intracellular hydrolysis of the amide linkage and localized intracellular pH changes are proposed as mechanisms. SWCNT-FC conjugates may serve as intracellular pH sensors.

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عنوان ژورنال:
  • Nanotechnology

دوره 20 29  شماره 

صفحات  -

تاریخ انتشار 2009